The Centre for Infectious Disease Research in Zambia (CIDRZ) has been an active partner of the Zambian Ministry of Health since inception and today our healthcare service programmes support more than 336 Government of the Republic of Zambia clinics located in all ten provinces. CIDRZ staff have played an instrumental role in the introduction and scale-up of Prevention of Mother-to-Child HIV Transmission (PMTCT) and adult and paediatric antiretroviral therapy (ART); integration of ART services into TB, Outpatient and Antenatal Clinics; introduction and expansion of innovative “See and Treat” diagnosis and treatment for cancer of the cervix; and scale-up of voluntary medical male circumcision services. CIDRZ research has contributed substantially to knowledge of improved ways to treat HIV and TB co-infected individuals, including children, and adult and perinatal HIV prevention as well as public health evaluations and strengthening health systems in the public health sector, including the Zambian Prison Services. With the generous support of many international donors, most notably the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) administered through the U.S. Centers for Disease Control and Prevention (CDC) in Zambia, CIDRZ has been able to support the delivery of lifesaving services through the public health system in collaboration with the Government of Zambia.